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Article

Role of Glutathione in Cancer Progression and Chemoresistance

1 Jan 2013

Abstract excerpt

Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis, and disturbances in GSH homeostasis are involved in the etiology and progression of many human diseases including cancer. While GSH deficiency, or a decrease in the GSH/glutathione disulphide (GSSG) ratio, leads to an increased susceptibility to oxidative stress implicated...

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PMID: 23766865
DOI: 10.1155/2013/972913

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