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Article

Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation.

The Journal of biological chemistry - 29 Apr 2005

Connor Kip M, Subbaram Sita, Regan Kevin J, Nelson Kristin K, Mazurkiewicz Joseph E, Bartholomew Peter J, Aplin Andrew E, Tai Yu-Tzu, Aguirre-Ghiso Julio, Flores Sonia C, Melendez J Andres

Abstract excerpt

Recent studies have demonstrated that the tumor suppressor PTEN (phosphatase and tensin homolog deleted from chromosome 10), the antagonist of the phosphosphoinositol-3-kinase (PI3K) signaling cascade, is susceptible to H2O2-dependent oxidative inactivation. This study describes the use of redox-...

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Identifiers

PMID: 15701646
DOI: 10.1074/jbc.M410690200

Genes

PTEN

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15701646-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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