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Article

Identification of interacting genes in genome-wide association studies using a model-based two-stage approach.

Annals of human genetics - 1 Sept 2010

Zhang Zhaogong, Niu Adan, Sha Qiuying

Abstract excerpt

In this paper, we propose a two-stage approach based on 17 biologically plausible models to search for two-locus combinations that have significant joint effects on the disease status in genome-wide association (GWA) studies. In the two-stage analyses, we only test two-locus joint effects of SNPs that show modest marginal effects. We use simulation studies to compare the power of our two-stage analysis with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20636464
DOI: 10.1111/j.1469-1809.2010.00594.x
PMCID: PMC2923239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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