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Article

Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice.

Science advances - 1 Feb 2020

Burgdorf Caitlin E, Jing Deqiang, Yang Ruirong, Huang Chienchun, Hill Matthew N, Mackie Ken, Milner Teresa A, Pickel Virginia M, Lee Francis S, Rajadhyaksha Anjali M

Abstract excerpt

Adolescence represents a developmental period with the highest risk for initiating cannabis use. Little is known about whether genetic variation in the endocannabinoid system alters mesolimbic reward circuitry to produce vulnerability to the rewarding properties of the exogenous cannabinoid Δ9-tetrahydrocannabinol (THC). Using a genetic knock-in mouse model (FAAHC/A) that biologically recapitulates the human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32095523
DOI: 10.1126/sciadv.aay1502
PMCID: PMC7015690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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