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Chronic adolescent exposure to cannabis in mice leads to sex-biased changes in gene expression networks across brain regions

22 Aug 2022

Abstract excerpt

During adolescence, frequent and heavy cannabis use can lead to serious adverse health effects and cannabis use disorder (CUD). Rodent models of adolescent exposure to the main psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC), mimic the behavioral alterations observed in adolescent users. However, the underlying molecular mechanisms remain largely unknown. Here, we treated female and male...

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PMID: 35995972
DOI: 10.1038/s41386-022-01413-2

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