Article
A model of human tumor dormancy: an angiogenic switch from the nonangiogenic phenotype.
Journal of the National Cancer Institute - 1 Mar 2006
Naumov George N, Bender Elise, Zurakowski David, Kang Soo-Young, Sampson David, Flynn Evelyn, Watnick Randolph S, Straume Oddbjorn, Akslen Lars A, Folkman Judah, Almog Nava
Abstract excerpt
BACKGROUND: Microscopic human cancers can remain dormant for life. Tumor progression depends on sequential events, including a switch to the angiogenic phenotype, i.e., initial recruitment of new vessels. We previously demonstrated that human tumors contain tumor cell populations that are heterogeneous in angiogenic activity. Here, we separated angiogenic from nonangiogenic human tumor cell populations and...
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