Article
Current concepts in the genetic diagnostics of rheumatoid arthritis.
Expert review of molecular diagnostics - 1 Jul 2010
Nagy Zsolt B, Csanád Mónika, Tóth Katalin, Börzsönyi Balázs, Demendi Csaba, Rigó János, Joó József Gábor
Abstract excerpt
Rheumatoid arthritis (RA) is a systemic, chronic and inflammatory disease of unknown etiology. HLA-DRB1 and PTPN22 1858T gene variants are risk factors of RA, clinical manifestations and rate of progression of joint destruction in this autoimmune disease. Currently, several immunopathogenetic models of other genes (CTLA4, MIF, PADI4 and SLC22A4) are under debate. The clinical influence of some of the gene...
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