Article
FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair.
Molecular and cellular biology - 24 Aug 2021
Kratz Katja, Artola-Borán Mariela, Kobayashi-Era Saho, Koh Gene, Oliveira Goncalo, Kobayashi Shunsuke, Oliveira Andreia, Zou Xueqing, Richter Julia, Tsuda Masataka, Sasanuma Hiroyuki, Takeda Shunichi, Loizou Joanna I, Sartori Alessandro A, Nik-Zainal Serena, Jiricny Josef
Abstract excerpt
Germline mutations in the mismatch repair (MMR) genes MSH2, MSH6, MLH1, and PMS2 are linked to cancer of the colon and other organs, characterized by microsatellite instability and a large increase in mutation frequency. Unexpectedly, mutations in EXO1, encoding the only exonuclease genetically implicated in MMR, are not linked to familial cancer and cause a substantially weaker mutator phenotype. This difference...
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