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Article

Multi-omics analysis identifies CpGs near G6PC2 mediating the effects of genetic variants on fasting glucose.

Diabetologia - 1 Jul 2021

Chung Ren-Hua, Chiu Yen-Feng, Wang Wen-Chang, Hwu Chii-Min, Hung Yi-Jen, Lee I-Te, Chuang Lee-Ming, Quertermous Thomas, Rotter Jerome I, Chen Yii-Der I, Chang I-Shou, Hsiung Chao A

Abstract excerpt

AIMS/HYPOTHESIS: An elevated fasting glucose level in non-diabetic individuals is a key predictor of type 2 diabetes. Genome-wide association studies (GWAS) have identified hundreds of SNPs for fasting glucose but most of their functional roles in influencing the trait are unclear. This study aimed to identify the mediation effects of DNA methylation between SNPs identified as significant from GWAS and fasting...

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PMID: 33842983
DOI: 10.1007/s00125-021-05449-9

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