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Article

BRAF V600E Expression in c-Kit+ Interstitial Cells of Cajal Drives Gastrointestinal Stromal Tumor Formation in Mice.

Cancer research communications - 1 Mar 2026

Tomassoni-Ardori Francesco, Reilly Karlyne M, Barrick Colleen, Koogle Robert, Edmondson Elijah F, Yanpallewar Sudhirkumar, Saur Dieter, Widemann Brigitte C, Glod John W, Tessarollo Lino

Abstract excerpt

Gastrointestinal stromal tumors (GIST) are rare sarcomas arising predominantly in the stomach and small intestine, with limited incidence in other gastrointestinal sites. GIST originates from c-KIT-/DOG1-positive interstitial cells of Cajal (ICC) most commonly driven by activating gain-of-function mutations in the c-KIT and PDGFRA genes. However, a subset of these malignancies, defined as wild-type GIST...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41697759
DOI: 10.1158/2767-9764.CRC-25-0725
PMCID: PMC13012002

Genes

BRAF
KIT
KRAS
NF1
PDGFRA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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