Article
Multiple intratumoral sources of kit ligand promote gastrointestinal stromal tumor.
Oncogene - 1 Aug 2023
Tieniber Andrew D, Rossi Ferdinando, Hanna Andrew N, Liu Marion, Etherington Mark S, Loo Jennifer K, Param Nesteene, Zeng Shan, Do Kevin, Wang Laura, DeMatteo Ronald P
Abstract excerpt
Gastrointestinal stromal tumor (GIST) is the most common human sarcoma and is typically driven by a single mutation in the Kit or PDGFRA receptor. While highly effective, tyrosine kinase inhibitors (TKIs) are not curative. The natural ligand for the Kit receptor is Kit ligand (KitL), which exists in both soluble and membrane-bound forms. While KitL is known to stimulate human GIST cell lines in vitro, we used a...
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