Article
Primary tumor genotype is an important determinant in identification of lung cancer propagating cells.
Cell stem cell - 2 Jul 2010
Curtis Stephen J, Sinkevicius Kerstin W, Li Danan, Lau Allison N, Roach Rebecca R, Zamponi Raffaella, Woolfenden Amber E, Kirsch David G, Wong Kwok-Kin, Kim Carla F
Abstract excerpt
Successful cancer therapy requires the elimination or incapacitation of all tumor cells capable of regenerating a tumor. Therapeutic advances therefore necessitate the characterization of the cells that are able to propagate a tumor in vivo. We show an important link between tumor genotype and isolation of tumor-propagating cells (TPCs). Three mouse models of the most common form of human lung cancer each had...
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