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Article

A novel method to generate single-cell-derived cancer-associated fibroblast clones.

Journal of cancer research and clinical oncology - 1 Aug 2017

Hashimoto Hiroko, Suda Yoshitaka, Miyashita Tomoyuki, Ochiai Atsushi, Tsuboi Masahiro, Masutomi Kenkichi, Kiyono Tohru, Ishii Genichiro

Abstract excerpt

BACKGROUND: Cancer-associated fibroblasts (CAFs) communicate with cancer cells to play important roles in tumor progression. However, CAFs have heterogeneous phenotypes and functions. To understand how much of this heterogeneity relates to different biological responses, a more efficient method of generating single-cell-derived CAF clones is required. METHOD: We transduced two primary CAF cultures (CAFs-608 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28364361
DOI: 10.1007/s00432-017-2409-3

Genes

HSF1
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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