Article
Molecular and functional properties of lung SP cells.
American journal of physiology. Lung cellular and molecular physiology - 1 Apr 2007
Reynolds Susan D, Shen Hongmei, Reynolds Paul R, Betsuyaku Tomoko, Pilewski Joseph M, Gambelli Federica, Di Giuseppe Michelangelo, DeGuiseppe Michelangelo, Ortiz Luis A, Stripp Barry R
Abstract excerpt
Previous analysis of lung injury and repair has provided evidence for region-specific stem cells that maintain proximal and distal epithelial compartments. However, redundant expression of lineage markers by cells at several levels of the stem cell hierarchy has complicated phenotypic and functional characterization of clonogenic airway cells. Based on the demonstration that rapid efflux of the DNA dye Hoechst...
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