Article
Characterization of melanoma cells capable of propagating tumors from a single cell.
Cancer research - 1 Jan 2010
Held Matthew A, Curley David P, Dankort David, McMahon Martin, Muthusamy Viswanathan, Bosenberg Marcus W
Abstract excerpt
Questions persist about the nature and number of cells with tumor-propagating capability in different types of cancer, including melanoma. In part, this is because identification and characterization of purified tumorigenic subsets of cancer cells has not been achieved to date. Here, we report tumor formation after injection of single purified melanoma cells derived from three novel mouse models. Tumor formation...
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