Article
The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis.
The Journal of biological chemistry - 12 Nov 2010
Golubkov Vladislav S, Chekanov Alexei V, Cieplak Piotr, Aleshin Alexander E, Chernov Andrei V, Zhu Wenhong, Radichev Ilian A, Zhang Danhua, Dong P Duc, Strongin Alex Y
Abstract excerpt
PTK7 is an essential component of the Wnt/planar cell polarity (PCP) pathway. We provide evidence that the Wnt/PCP pathway converges with pericellular proteolysis in both normal development and cancer. Here, we demonstrate that membrane type-1 matrix metalloproteinase (MT1-MMP), a key proinvasive proteinase, functions as a principal sheddase of PTK7. MT1-MMP directly cleaves the exposed PKP(621)↓LI sequence of...
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