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Article

Association of CYP3A5 polymorphisms with hypertension and antihypertensive response to verapamil.

Clinical pharmacology and therapeutics - 1 Mar 2007

Langaee T Y, Gong Y, Yarandi H N, Katz D A, Cooper-DeHoff R M, Pepine C J, Johnson J A

Abstract excerpt

In the CYP3A5 gene, the A>G (*3) and G>A (*6) polymorphisms result in severely decreased expression of CYP3A5 enzyme relative to a normal functional allele (*1). We sought to determine if the CYP3A5 genetic polymorphisms were associated with level of blood pressure (BP), risk of hypertension (HTN), and the antihypertensive response to verapamil. A total of 676 normotensive and hypertensive participants (mean age...

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Source

Identifiers

PMID: 17339868
DOI: 10.1038/sj.clpt.6100090

Genes

DBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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