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Article

Sustained Expression of TDP-43 and FUS in Motor Neurons in Rodent's Lifetime

1 Jan 2010

Abstract excerpt

TAR DNA-binding protein (TDP-43) and fused in sarcoma (FUS) are two highly conserved ribonucleoproteins. Pathogenic mutations of the TDP-43 or the FUS gene are all linked to amyotrophic lateral sclerosis (ALS) that is characterized by progressive degeneration of motor neurons. To better understand the correlation of ALS disease genes with the selectivity of chronic motor neuron degeneration, we examined the...

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PMID: 20616880
DOI: 10.7150/ijbs.6.396

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