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Article

Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion

8 Sept 2012

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are relentlessly progressive neurodegenerative disorders with overlapping clinical, genetic and pathological features. Cytoplasmic inclusions of fused in sarcoma (FUS) are the hallmark of several forms of FTLD and ALS patients with mutations in the FUS gene. FUS is a multifunctional, predominantly nuclear, DNA and RNA binding...

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PMID: 22961620
DOI: 10.1007/s00401-012-1043-z

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