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Article

Understanding the role of TDP-43 and FUS/TLS in ALS and beyond.

Current opinion in neurobiology - 1 Dec 2011

Da Cruz Sandrine, Cleveland Don W

Abstract excerpt

Dominant mutations in two DNA/RNA binding proteins, TDP-43 and FUS/TLS, are causes of inherited Amyotrophic Lateral Sclerosis (ALS). TDP-43 and FUS/TLS have striking structural and functional similarities, implicating alterations in RNA processing as central in ALS. TDP-43 has binding sites within a third of all mouse and human mRNAs in brain and this binding influences the levels and splicing patterns of at...

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Source

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Identifiers

PMID: 21813273
DOI: 10.1016/j.conb.2011.05.029
PMCID: PMC3228892

Genes

FUS
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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