Article
The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span.
The Journal of clinical investigation - 1 Oct 2011
Wang Ji-Wu, Brent Jonathan R, Tomlinson Andrew, Shneider Neil A, McCabe Brian D
Abstract excerpt
The fatal adult motor neuron disease amyotrophic lateral sclerosis (ALS) shares some clinical and pathological overlap with frontotemporal dementia (FTD), an early-onset neurodegenerative disorder. The RNA/DNA-binding proteins fused in sarcoma (FUS; also known as TLS) and TAR DNA binding protein-43 (TDP-43) have recently been shown to be genetically and pathologically associated with familial forms of ALS and...
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