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Article

Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy

2 Apr 2012

Abstract excerpt

The mouse zona pellucida is composed of three glycoproteins (ZP1, ZP2, and ZP3), of which ZP2 is proteolytically cleaved after gamete fusion to prevent polyspermy. This cleavage is associated with exocytosis of cortical granules that are peripherally located subcellular organelles unique to ovulated eggs. Based on the cleavage site of ZP2, ovastacin was selected as a candidate protease. Encoded by the single-copy...

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PMID: 22472438
DOI: 10.1083/jcb.201112094

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