Article
Towards the Molecular Basis of Sperm and Egg Interaction during Mammalian Fertilization
24 Nov 2000
Abstract excerpt
During the past 2 decades, a number of genes have been cloned from mammals which encode polypeptides that participate in the process of fertilization. Among these are glycoproteins ZP1-3 that constitute the zona pellucida of eggs from mice to human beings. In mice, one of these glycoproteins, mZP3, acts as a primary sperm receptor and acrosome reaction-inducer. The evidence suggests that acrosome-intact sperm...
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