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Article

Direct and rapid genotyping of glutathione-S-transferase M1 and T1 from human blood specimens using the SmartAmp2 method.

Drug metabolism and disposition: the biological fate of chemicals - 1 Oct 2010

Okada Ran, Ishizu Yuri, Endo Ryuta, Lezhava Alexander, Ieiri Ichiro, Kusuhara Hiroyuki, Sugiyama Yuichi, Hayashizaki Yoshihide

Abstract excerpt

Clinical studies have suggested that a defect in both glutathione S-transferase (GST) M1 and GSTT1 increases the risk of drug-induced hepatotoxicity. The present study developed the method that enables genotyping of GSTM1 and GSTT1 directly using a small aliquot of blood samples based on an isothermal Smart amplification process version 2 (SmartAmp-2). SmartAmp-2 reaction could complete the genotyping of GSTM1...

Read the complete abstract on PubMed

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Share to Chemical and Drug Induced Liver Injury
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

Source

Identifiers

PMID: 20610557
DOI: 10.1124/dmd.110.034652

Genes

GSTT1
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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