Article
[Development of simplified and rapid detection assay for genetic polymorphisms influencing drug response and its clinical applications].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan - 1 Jul 2002
Hiratsuka Masahiro
Abstract excerpt
Clinically important genetic polymorphisms influencing drug metabolism and drug response have typically been discovered on the basis of phenotypic differences among individuals from different populations. Routine genotyping before drug therapy may enable the identification of responders, nonresponders, or patients at increased risk of toxicity. Automated, high-throughput detecting methods for single-nucleotide...
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