Article
Pharmacogenomics of human ABC transporters: detection of clinically important SNPs by SmartAmp2 method.
Current pharmaceutical biotechnology - 1 Apr 2011
Aw Wanping, Ota Ikuko, Toyoda Yu, Lezhava Alexander, Sakai Yasuo, Gomi Tsuneaki, Hayashizaki Yoshihide, Ishikawa Toshihisa
Abstract excerpt
Genetic polymorphisms and mutations in drug metabolizing enzymes, transporters, receptors, and other drug targets (e.g., toxicity targets) are linked to inter-individual differences in the efficacy and toxicity of many medications as well as risk of genetic diseases. Validation of clinically important genetic polymorphisms and the development of new technologies to rapidly detect clinically important variants are...
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