Article
Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility.
Carcinogenesis - 1 Sept 2010
Lascorz Jesús, Försti Asta, Chen Bowang, Buch Stephan, Steinke Verena, Rahner Nils, Holinski-Feder Elke, Morak Monika, Schackert Hans K, Görgens Heike, Schulmann Karsten, Goecke Timm, Kloor Matthias, Engel Cristoph, Büttner Reinhard, Kunkel Nelli, Weires Marianne, Hoffmeister Michael, Pardini Barbara, Naccarati Alessio, Vodickova Ludmila, Novotny Jan, Schreiber Stefan, Krawczak Michael, Bröring Clemens D, Völzke Henry, Schafmayer Clemens, Vodicka Pavel, Chang-Claude Jenny, Brenner Hermann, Burwinkel Barbara, Propping Peter, Hampe Jochen, Hemminki Kari
Abstract excerpt
Genetic susceptibility accounts for approximately 35% of all colorectal cancer (CRC). Ten common low-risk variants contributing to CRC risk have been identified through genome-wide association studies (GWASs). In our GWAS, 610 664 genotyped single-nucleotide polymorphisms (SNPs) passed the quality control filtering in 371 German familial CRC patients and 1263 controls, and replication studies were conducted in...
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