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Article

Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases.

Journal of clinical pathology - 1 Sept 2016

Malapelle Umberto, Pisapia Pasquale, Sgariglia Roberta, Vigliar Elena, Biglietto Maria, Carlomagno Chiara, Giuffrè Giuseppe, Bellevicine Claudio, Troncone Giancarlo

Abstract excerpt

AIMS: The incidence of RAS/RAF/PI3KA and TP53 gene mutations in colorectal cancer (CRC) is well established. Less information, however, is available on other components of the CRC genomic landscape, which are potential CRC prognostic/predictive markers. METHODS: Following a previous validation study, ion-semiconductor next-generation sequencing (NGS) was employed to process 653 routine CRC samples by a multiplex...

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PMID: 26797410
DOI: 10.1136/jclinpath-2015-203403
PMCID: PMC5036215

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AKT1
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