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Article

Recurrent, low-frequency coding variants contributing to colorectal cancer in the Swedish population.

PloS one - 1 Jan 2018

Jiao Xiang, Liu Wen, Mahdessian Hovsep, Bryant Patrick, Ringdahl Jenny, Timofeeva Maria, Farrington Susan M, Dunlop Malcolm, Lindblom Annika

Abstract excerpt

Genome-wide association studies (GWAS) have identified dozens of common genetic variants associated with risk of colorectal cancer (CRC). However, the majority of CRC heritability remains unclear. In order to discover low-frequency, high-risk CRC susceptibility variants in Swedish population, we genotyped 1 515 CRC patients enriched for familial cases, and 12 108 controls. Case/control association analysis...

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Identifiers

PMID: 29547645
DOI: 10.1371/journal.pone.0193547
PMCID: PMC5856271

Genes

NEU1
PSMA8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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