Article
Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12.
Current biology : CB - 21 Sept 2000
Takada S, Tevendale M, Baker J, Georgiades P, Campbell E, Freeman T, Johnson M H, Paulsen M, Ferguson-Smith A C
Abstract excerpt
The distal portion of mouse chromosome 12 is imprinted. To date, however, Gtl2 is the only imprinted gene identified on chromosome 12. Gtl2 encodes multiple alternatively spliced transcripts with no apparent open reading frame. Using conceptuses with maternal or paternal uniparental disomy for chromosome 12 (UPD12), we found that Gtl2 is expressed from the maternal allele and methylated at the 5' end of the...
Topics
- Alleles
- Animals
- Chromosomes
- DNA
- DNA Methylation
- Embryo, Mammalian
- Gene Expression Regulation, Developmental
- Genomic Imprinting
- Homeodomain Proteins
- Intracellular Signaling Peptides and Proteins
- Membrane Proteins
- Mice
- RNA, Messenger