Article
Establishment of paternal allele-specific DNA methylation at the imprinted mouse Gtl2 locus.
Epigenetics - 1 Aug 2011
Nowak Kamila, Stein Geneva, Powell Elizabeth, He Lu Mei, Naik Snehal, Morris Jane, Marlow Sara, Davis Tamara L
Abstract excerpt
The monoallelic expression of imprinted genes is controlled by epigenetic factors including DNA methylation and histone modifications. In mouse, the imprinted gene Gtl2 is associated with two differentially methylated regions: the IG-DMR, which serves as a gametic imprinting mark at which paternal allele-specific DNA methylation is inherited from sperm, and the Gtl2-DMR, which acquires DNA methylation on the...
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