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Identification of an imprinted gene, <i>Meg3</i>/<i>Gtl2</i> and its human homologue <i>MEG3</i>, first mapped on mouse distal chromosome 12 and human chromosome 14q

1 Mar 2000

Abstract excerpt

BACKGROUND: The paternal duplication of mouse distal chromosome 12 leads to late embryonal/neonatal lethality and growth promotion, whereas maternal duplication leads to late embryonal lethality and growth retardation. Human paternal or maternal uniparental disomies of chromosome 14q that are syntenic to mouse distal chromosome 12 have also been reported to show some imprinting effects on growth, mental activity...

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Identifiers

PMID: 10759892
DOI: 10.1046/j.1365-2443.2000.00320.x

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Related research

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Research trail→

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Identification of an imprinted gene, <i>Meg3</i>/<i>Gtl2</i> and its human homologue <i>MEG3</i>, first mapped on mouse distal chromosome 12 and human chromosome 14qPMID 10759892Read ↗

Identification of the <i>Meg1</i> / <i>Grb10</i> imprinted gene on mouse proximal chromosome 11, a candidate for the Silver–Russell syndrome geneSemantic proximity Read ↗

Mouse <i>Peg9/Dlk1</i> and human <i>PEG9/DLK1</i> are paternally expressed imprinted genes closely located to the maternally expressed imprinted genes: mouse <i>Meg3/Gtl2</i> and human <i>MEG3</i>Semantic proximity Read ↗

At Least Ten Genes Define the Imprinted Dlk1-Dio3 Cluster on Mouse Chromosome 12qF1Semantic proximity Read ↗

Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene.Semantic proximity Read ↗

Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12.Semantic proximity Read ↗

Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardationSemantic proximity Read ↗

Imprinting regulation of the murine Meg1/Grb10 and human GRB10 genes; roles of brain-specific promoters and mouse-specific CTCF-binding sites.Semantic proximity Read ↗

Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12Semantic proximity Read ↗

Restricted co-expression of Dlk1 and the reciprocally imprinted non-coding RNA, Gtl2: implications for cis-acting control.Semantic proximity Read ↗

Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes.Semantic proximity Read ↗

Identification of Grf1 on mouse chromosome 9 as an imprinted gene by RLGS–MSemantic proximity Read ↗

<i>peg10</i>, an imprinted gene, plays a crucial role in adipocyte differentiationSemantic proximity Read ↗

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