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Article

Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target.

The Journal of pathology - 1 Jun 2012

Gerlinger Marco, Santos Claudio R, Spencer-Dene Bradley, Martinez Pierre, Endesfelder David, Burrell Rebecca A, Vetter Marcus, Jiang Ming, Saunders Rebecca E, Kelly Gavin, Dykema Karl, Rioux-Leclercq Nathalie, Stamp Gordon, Patard Jean Jacques, Larkin James, Howell Michael, Swanton Charles

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of kidney cancer. Here, we integrated an unbiased genome-wide RNA interference screen for ccRCC survival regulators with an analysis of recurrently overexpressed genes in ccRCC to identify new therapeutic targets in this disease. One of the most potent survival regulators, the monocarboxylate transporter MCT4 (SLC16A3), impaired ccRCC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22362593
DOI: 10.1002/path.4006
PMCID: PMC3504091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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