Article
Evidence for a dominant gene mechanism underlying coeliac disease in the west of Ireland.
Genetic epidemiology - 1 Jan 1991
Hernández J L, Michalski J P, McCombs C C, McCarthy C F, Stevens F M, Elston R C
Abstract excerpt
Although coeliac disease (CD) is strongly associated with the HLA alleles B8 and DR3, the genetic basis of this illness remains obscure. Recent studies show that at least two unlinked loci are involved. Most studies agree on recessivity at the HLA-unlinked locus but differ with respect to dominance or recessivity at the HLA-linked disease susceptibility locus. To address this controversy, we examined the...
Topics
- Alleles
- Celiac Disease
- Female
- Genes, Dominant
- Genetic Linkage
- Genotype
- HLA-A Antigens
- HLA-B Antigens
- HLA-DR Antigens
- Histocompatibility Testing
- Humans
- Ireland