Article
Akt activation is a common event in pediatric malignant gliomas and a potential adverse prognostic marker: a report from the Children's Oncology Group.
Journal of neuro-oncology - 1 Sept 2010
Pollack Ian F, Hamilton Ronald L, Burger Peter C, Brat Daniel J, Rosenblum Marc K, Murdoch Geoffrey H, Nikiforova Marina N, Holmes Emiko J, Zhou Tianni, Cohen Kenneth J, Jakacki Regina I
Abstract excerpt
Aberrant activation of Akt is a common finding in adult malignant gliomas, resulting in most cases from mutations or deletions involving PTEN, which allows constitutive Akt phosphorylation. In contrast, we have previously reported that pediatric malignant gliomas, which are morphologically similar to lesions arising in adults, have a substantially lower incidence of genomic alterations of PTEN. The objective of...
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