Article
ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2003
Gilbertson Richard J, Hill D Ashley, Hernan Roberto, Kocak Mehmet, Geyer Russell, Olson Jim, Gajjar Amar, Rush Lisa, Hamilton Ronald L, Finkelstein Sydney D, Pollack Ian F
Abstract excerpt
PURPOSE: This study was conducted to investigate the incidence of ERBB1 amplification and overexpression in samples of diffusely infiltrative (WHO grades II-IV) pediatric brain stem glioma (BSG) and determine the relationship of these abnormalities to expression and mutation of TP53 and tumor grade. EXPERIMENTAL DESIGN: After central pathology review, the incidence of ERBB1 amplification and overexpression was...
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