B16 melanoma variants selected by one or more cycles of spontaneous metastasis to the same organ fail to exhibit organ specificity.

Abstract excerpt

Metastatic clones of the mouse B16 melanoma spontaneously disseminate from subcutaneous tumors throughout the body in two stages, initially to the lungs and secondarily from established lung metastases to systemic sites. From the heterogeneous 'parent' B16 melanoma cell line and from two representative clones, G3.5 and G3.12, cell populations were selected after one or more cycles of tumor growth or metastasis to...

Topics

• Animals
• Female
• Genetic Variation
• Melanoma, Experimental
• Mice
• Mice, Inbred Strains
• Neoplasm Metastasis
• Organ Specificity
• Tumor Cells, Cultured