Article
Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease.
Human molecular genetics - 1 Sept 2010
Fransen Karin, Visschedijk Marijn C, van Sommeren Suzanne, Fu Jinyuan Y, Franke Lude, Festen Eleonora A M, Stokkers Pieter C F, van Bodegraven Adriaan A, Crusius J Bart A, Hommes Daniel W, Zanen Pieter, de Jong Dirk J, Wijmenga Cisca, van Diemen Cleo C, Weersma Rinse K
Abstract excerpt
Genome-wide association studies (GWAS) for Crohn's disease (CD) have identified loci explaining approximately 20% of the total genetic risk of CD. Part of the other genetic risk loci is probably partly hidden among signals discarded by the multiple testing correction needed in the analysis of GWAS data. Strategies for finding these hidden loci require large replication cohorts and are costly to perform. We...
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