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Article

Cell homeostasis in a Leishmania major mutant overexpressing the spliced leader RNA is maintained by an increased proteolytic activity.

The international journal of biochemistry & cell biology - 1 Oct 2010

Toledo Juliano S, Ferreira Tiago R, Defina Tânia P A, Dossin Fernando de M, Beattie Kenneth A, Lamont Douglas J, Cloutier Serge, Papadopoulou Barbara, Schenkman Sergio, Cruz Angela K

Abstract excerpt

Although several stage-specific genes have been identified in Leishmania, the molecular mechanisms governing developmental gene regulation in this organism are still not well understood. We have previously reported an attenuation of virulence in Leishmania major and L. braziliensis carrying extra-copies of the spliced leader RNA gene. Here, we surveyed the major differences in proteome and transcript expression...

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PMID: 20601086
DOI: 10.1016/j.biocel.2010.06.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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