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Developmental regulation of gene expression in the absence of transcriptional control: The case of kinetoplastids

17 Oct 2011

Abstract excerpt

Kinetoplastids, including the human pathogens Trypanosoma brucei, Trypanosoma cruzi and Leishmania, are the only known organisms that do not regulate the transcription of protein coding genes transcribed by RNA polymerase II. Yet, profound changes in gene expression are induced by many different external stimuli and stresses, the extreme example are cascades of changes in gene expression initiated by...

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PMID: 22019385
DOI: 10.1016/j.molbiopara.2011.10.002

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