Article
Leishmania major virulence attenuation in vitro: An old conundrum revisited in the omics era.
PLoS neglected tropical diseases - 1 May 2026
Gerasimov Evgeny S, Záhonová Kristína, Ishemgulova Aygul, Novozhilova Tatiana S, Mishra Sai Kumar, Kraeva Natalya, Sádlová Jovana, Volf Petr, Zimmer Sara L, Yurchenko Vyacheslav
Abstract excerpt
BACKGROUND: It has been known for decades that long-term cultivation of Leishmania in vitro frequently leads to a loss of virulence, which is attributed to the selective advantage of avirulent subpopulations that outgrow the virulent ones. In the case of L. major, avirulent parasites retained the ability, albeit reduced, to develop nearly normally in sand fly vectors; however, they could not induce lesions in...
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