Back to search

Article

Five-layer systems analysis of <i>Leishmania</i> stage differentiation reveals an essential role for protein degradation in parasite development

2025-03-28

Abstract excerpt

<h4>ABSTRACT</h4> Vector-borne, protist parasites have evolved complex developmental programs to adapt to very distinct host environments. How these important pathogens transition between insect and mammalian stages is only poorly understood. Here we investigate stage differentiation in the trypanosomatid parasite Leishmania that shows constitutive gene transcription, thus providing a unique model system to asse...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
afde096c-e0c3-5ef4-90f2-36ef6a966a6b
DOI
10.1101/2025.03.24.644963
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Five-layer systems analysis of <i>Leishmania</i> stage differentiation reveals an essential role for protein degradation in parasite developmentDOI 10.1101/2025.03.24.644963
Transcriptomic analysis reveals metabolic switches and surface remodeling as key processes for stage transition in <i>Trypanosoma cruzi</i>Semantic proximity
Transcriptomic profiling of gene expression and RNA processing during Leishmania major differentiationSemantic proximity
Transcriptomic analysis reveals metabolic switches and surface remodeling as key processes for stage transition in Trypanosoma cruziSemantic proximity
Single-cell transcriptomics to define <i>Plasmodium falciparum</i> stage-transition in the mosquito midgutSemantic proximity
Quantitative proteomics of <i>Trypanosoma cruzi</i> during metacyclogenesisSemantic proximity
Phosphoproteomic Analysis of Differentiating <i>Leishmania</i> Parasites Reveals a Unique Stage-Specific Phosphorylation MotifSemantic proximity
Initiation codon context governs translation-coupled mRNA decay and coordinated expression in the human parasite <i>Leishmania</i>Semantic proximity
Single cell transcriptomic analysis of bloodstream form <i>Trypanosoma brucei</i> reconstructs cell cycle progression and differentiation via quorum sensingSemantic proximity
The mRNA-bound proteome of <i>Leishmania mexicana</i> : novel genetic insight into an ancient parasiteSemantic proximity
Developmental regulation of gene expression in the absence of transcriptional control: The case of kinetoplastidsSemantic proximity
Comparative and systems analyses of <i>Leishmania</i> spp. non-coding RNAs through developmental stagesSemantic proximity
Single-cell transcriptomics reveals a multiphasic <i>Wolbachia</i> host infection trajectorySemantic proximity
Select a neighboring publication to make it the new centre.