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Article

Effect of interleukin-4 on interleukin-2-dependent generation of natural killer cells.

Cellular immunology - 1 Aug 1991

Migliorati G, Cardinali L, Riccardi C

Abstract excerpt

We have previously shown that interleukin-2 (IL-2) is able to induce the generation of natural killer (NK) activity in bone marrow (BM) cells from mice pretreated with 5-fluorouracil. IL-2 alone could dose-dependently induce NK activity in marrow cells and interleukin-4 (IL-4) has dual effect on the NK activity in that, depending on the concentration of IL-2, IL-4 inhibits or stimulates development of NK cells....

Topics

Animals
Cell Cycle
Cells, Cultured
Cytotoxicity, Immunologic
Female
Interleukin-1
Interleukin-2
Interleukin-4
Killer Cells, Natural
Male
Mice
Mice, Inbred C3H

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Receptors, Interleukin-2

Spleen

Source

Identifiers

PMID: 2060020
DOI: 10.1016/0008-8749(91)90394-q

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2060020-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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