Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NKG2D Engagement Alone Is Sufficient to Activate Cytokine-Induced Killer Cells While 2B4 Only Provides Limited Coactivation.

Frontiers in immunology - 1 Jan 2021

Wu Xiaolong, Sharma Amit, Oldenburg Johannes, Weiher Hans, Essler Markus, Skowasch Dirk, Schmidt-Wolf Ingo G H

Abstract excerpt

Cytokine-induced killer (CIK) cells are an ex vivo expanded heterogeneous cell population with an enriched NK-T phenotype (CD3+CD56+). Due to the convenient and relatively inexpensive expansion capability, together with low incidence of graft versus host disease (GVHD) in allogeneic cancer patients, CIK cells are a promising candidate for immunotherapy. It is well known that natural killer group 2D (NKG2D) plays...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Degranulation
Share to Coculture Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytotoxicity, Immunologic

Share to Histocompatibility Antigens Class I

Share to Interferon-gamma

Share to K562 Cells

Share to Lymphocyte Function-Associated Antigen-1

Share to NK Cell Lectin-Like Receptor Subfamily K

Source

Open in PubMed Open full text

Identifiers

PMID: 34691037
DOI: 10.3389/fimmu.2021.731767
PMCID: PMC8529192

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NKG2D Engagement Alone Is Sufficient to Activate Cytokine-Induced Killer Cells While 2B4 Only Provides Limited Coactivation.PMID 34691037Read ↗

Cytokine-induced killer (CIK) cells as feasible and effective adoptive immunotherapy for the treatment of solid tumors.Semantic proximity Read ↗

Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient HumansSemantic proximity Read ↗

Advances in NKG2D ligand recognition and responses by NK cellsSemantic proximity Read ↗

NKG2D Ligands in Tumor Immunity: Two Sides of a CoinSemantic proximity Read ↗

Leveraging NKG2D Ligands in Immuno-OncologySemantic proximity Read ↗

Cytokine induced killer cells as adoptive immunotherapy strategy to augment graft versus tumor after hematopoietic cell transplantation.Semantic proximity Read ↗

Recent Progress in NKG2D CAR-NK Cells for Cancer ImmunotherapySemantic proximity Read ↗

Genetically modified and unmodified cellular approaches to enhance graft versus leukemia effect, without increasing graft versus host disease: the use of allogeneic cytokine-induced killer cellsSemantic proximity Read ↗

Thymoglobulin, interferon-γ and interleukin-2 efficiently expand cytokine-induced killer (CIK) cells in clinical-grade cultures.Semantic proximity Read ↗

Targeting NKG2A to elucidate natural killer cell ontogenesis and to develop novel immune-therapeutic strategies in cancer therapySemantic proximity Read ↗

NKG2D signaling in cancer immunosurveillanceSemantic proximity Read ↗

Functional Dichotomy between NKG2D and CD28-Mediated Co-Stimulation in Human CD8+ T CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.