Killer-cell inhibitory receptors, CD158a/b, are upregulated by interleukin-2, but not interferon-gamma or interleukin-4.

doi:10.1080/09629359990324

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Article

Killer-cell inhibitory receptors, CD158a/b, are upregulated by interleukin-2, but not interferon-gamma or interleukin-4.

Mediators of inflammation - 1 Jan 1999

Kogure T, Fujinaga H, Niizawa A, Hai L X, Shimada Y, Ochiai H, Terasawa K

Abstract excerpt

Although it is now accepted that killer-cell inhibitory receptors (KIRs), which were molecularly cloned in 1995, deliver negative signals to natural killer (NK) cells regarding the recognition of target cells, it is still unclear how the expression of these receptors on lymphocytes is regulated. Therefore, we investigated the regulation of expression of representative KIRs, CD158a and CD158b, by cytokines such as...

Topics

Cells, Cultured
Humans
Interferon-gamma
Interleukin-2
Interleukin-4
Killer Cells, Natural
Phenotype
Receptors, Immunologic
Receptors, KIR
Receptors, KIR2DL1
Receptors, KIR2DL3
Up-Regulation

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Identifiers

PMID: 10815620
DOI: 10.1080/09629359990324
PMCID: PMC1781812

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