Article
rIL-4 differentially regulates rIL-2-induced murine NK and LAK killing in CD8+ and CD8- precursor cell subsets.
International immunology - 1 Jun 1991
Merrow M W, Huber B T
Abstract excerpt
Interleukin 4 (IL-4) and IL-2 have complementary or synergistic roles in many aspects of lymphocyte development. IL-2 supports the induction of cytolytic activity in cytotoxic T lymphocyte (CTL), natural killer (NK), and lymphokine-activated killer (LAK) cells. IL-4 has also been shown to support CTL and LAK in primary murine spleen cell culture. This report demonstrates that IL-4 selectively down-regulates IL-2...
Topics
- Animals
- Antigens, Differentiation, T-Lymphocyte
- CD8 Antigens
- Cytotoxicity, Immunologic
- Down-Regulation
- Hematopoietic Stem Cells
- In Vitro Techniques
- Interleukin-2
- Interleukin-4
- Killer Cells, Lymphokine-Activated
- Killer Cells, Natural