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Article

Hyaluronic acid metabolism is increased in unstable plaques.

European journal of clinical investigation - 1 Sept 2010

Bot Pieter T, Pasterkamp Gerard, Goumans Marie-José, Strijder Chaylendra, Moll Frans L, de Vries Jean-Paul, Pals Steven T, de Kleijn Dominique P, Piek Jan J, Hoefer Imo E

Abstract excerpt

BACKGROUND: Hyaluronic acid is expressed in atherosclerotic lesions, but its exact role in atherosclerotic disease remains unknown. As degradation of hyaluronic acid by hyaluronidase into low molecular weight hyaluronic acid (LMW-HA) is associated with inflammation and Matrix Metalloproteinase (MMP)-9 activity, we hypothesized that hyaluronic acid metabolism is increased in plaques with unstable characteristics...

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Identifiers

PMID: 20597964
DOI: 10.1111/j.1365-2362.2010.02326.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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