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Article

Differential accumulation of proteoglycans and hyaluronan in culprit lesions: insights into plaque erosion.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2002

Kolodgie Frank D, Burke Allen P, Farb Andrew, Weber Deena K, Kutys Robert, Wight Thomas N, Virmani Renu

Abstract excerpt

OBJECTIVE: The importance of the extracellular matrix molecules versican, biglycan, decorin, and hyaluronan in plaque instability has not been recognized. METHODS AND RESULTS: Coronary lesions with acute thrombi and stable plaques were examined for the accumulation and distribution of specific proteoglycans and hyaluronan at culprit sites. The cell surface receptor for hyaluronan, CD44, and smooth muscle (SM)...

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Identifiers

PMID: 12377743
DOI: 10.1161/01.atv.0000034021.92658.4c

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