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Article

Etanercept reduces matrix metalloproteinase-9 level in children with polyarticular juvenile idiopathic arthritis and TNF-alpha-308GG genotype.

Journal of physiology and biochemistry - 1 Jun 2010

Basic Jelena, Pavlovic Dusica, Jevtovic-Stoimenov Tatjana, Vojinovic Jelena, Susic Gordana, Stojanovic Ivana, Kocic Gordana, Milosevic Vuk, Cvetkovic Tatjana, Marinkovic Milena, Veljkovic Andrej

Abstract excerpt

Genetic contribution of tumor necrosis factor polymorphism (TNF-alpha-308G/A) in patients with juvenile idiopathic arthritis (JIA) on response to TNF blocking agents, as well as matrix metalloproteinase-9 (MMP-9) production, is not yet well established. We have investigated whether the TNF-alpha-308G/A polymorphism can influence MMP-9 level and clinical response to etanercept (TNF receptor II-Fc fusion protein)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20596903
DOI: 10.1007/s13105-010-0022-x

Genes

TNF
ACR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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