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Article

Tumor necrosis factor-alpha -308 genotypes influence inflammatory activity and TNF-alpha serum concentrations in children with juvenile idiopathic arthritis.

The Journal of rheumatology - 1 Apr 2009

Mourão Ana Filipa, Caetano-Lopes Joana, Costa Paula, Canhão Helena, Santos Maria José, Pinto Patrícia, Brito Iva, Nicola Paulo, Cavaleiro João, Teles José, Sousa Artur, Gomes José Melo, Branco Jaime, da Costa José Teixeira, Pedro João Gomes, de Queiroz Mário Viana, Fonseca João Eurico

Abstract excerpt

OBJECTIVE: Considering the relevance of tumor necrosis factor-alpha (TNF-alpha) in the pathophysiology of juvenile idiopathic arthritis (JIA), it is likely that polymorphisms in its promoter area may be relevant in disease susceptibility and activity. We investigated if clinical measures of JIA activity and TNF-alpha serum concentrations were associated with TNF-alpha -308 genotypes. METHODS: Portuguese patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

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Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 19208590
DOI: 10.3899/jrheum.080615

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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